RRs (95% CI) from full, ischemic, and hemorrhagic strokes by the quintiles off combined diet ratings to own magnesium, potassium, and calcium intakes during the 86,149 ladies in the brand new NHS I and you can 94,715 women in this new NHS II step one
I current the newest meta-analyses out of prospective education regarding dieting magnesium ( 21), potassium ( 22), and calcium supplements ( 23) intakes and threat of coronary arrest
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
RRs (95% CI) off total, ischemic, and hemorrhagic strokes from the quintiles from shared diet score to own magnesium, potassium, and you can calcium consumption from inside the 86,149 feamales in the fresh new NHS We and you may 94,715 women in the new NHS II 1
We current the newest meta-analyses from possible studies out-of slimming down magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) intakes and you may threat of coronary arrest
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We tested complete and you may weight-loss intakes each and every mineral and exposure of heart attack to choose any potential nonlinear https://datingranking.net/sapiosexual-dating/ organization that with restricted cubic splines; yet not, no high deviation off linearity are observed. At exactly the same time, i looked the potential impact modification by ages, blood pressure levels, otherwise all forms of diabetes towards the loved ones anywhere between full consumption of all the step three nutritional elements and you will chance of full heart attack. No tall effect modification are noticed from the these factors.
Earlier in the day meta-analyses included comes from previous analyses throughout the NHS ( 10); these types of abilities were replaced by results in the current data. As well, the fresh new literature was appeared, and recent prospective knowledge ( 8, 24) had been utilized in such updated meta-analyses. Zero anywhere between-education heterogeneity is seen when it comes down to of your own step 3 nutrients. New shared RR of complete coronary attack was 0.87 (95% CI: 0.83, 0.92) having an one hundred-mg/d boost out-of magnesium intake, 0.91 (95% CI: 0.88, 0.94) to possess an excellent a thousand-mg/d boost out-of potassium consumption, and you may 0.98 (95% CI: 0.94, step 1.02) to own a 300-mg/d raise away from calcium consumption.
